Cell to Singularity Wiki

Entropy is the first currency in the game, and is used to power biological evolution and grow from species to species. It can be generated from the very start of the game, simply by tapping on the background of any play area. Over time, as you create new life forms (Generators such as DNA and Amino Acids) and Upgrades, more Entropy will be generated both passively from your purchases and from Tapping lots

Other forms of currency, like Darwinium, can help out a lot when you're low on Entropy. They can trigger Quantum Triggers which can give you extra Entropy, at the cost of 4 Darwinium, and a Time Flux for 3 Darwinium. If you're offline more, you get more Entropy and more ideas. Being offline until 18 hours 18 minutes if you have more time of sleep more in the next morning your entropy and ideas are boosted